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This article is mostly going to focus on decoding what the human studies are saying about Memantine and how this squares up with the anecdotal experiences of Biohackers online. Memantine Dosage. As soon as I got it, I stupidly took a recreational dose of 50mg when the original reason I purchased it was to help with my gabapentin and eventually ativan taper. memantine. Memantine is great. This year was hardcore shity. Likewise the Lexapro flipped me from a constantly depressed state to a euphoric one around the third or fourth day of dosing. I'm not entirely sure why, but I'm an extremely rapid responder to SSRI's. My depression has never been consistent with MDD, but rather almost like episodic bouts of hysteria. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. Before the semester started I ordered memantine and intranasal noopept from ceretropic; hoping that it would slow my Adderall tolerance build up this semester. Age and the condition you are treating are key determinants. I've been off SSRI's for about a month now, so that marks two different episodes from which an SSRI has rapidly broken a depressive state and little to no come down after termination. Memantine (Akatinol memantine), an agent that is approved in Germany for dementia syndrome, Parkinson's disease has significant antiglutamatergic and neuroprotective properties, may prove to have antidepressant properties in depressed patients. The Addy cured all of my brain ails for about a week. In addition to its glutamatergic modulation, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors (nAChR). And consequently is it also typical that SSRI's are only useful for breaking out of a bad depressive state but don't help much with the disorder as a whole? Like, im looking at world from inside and dont feel like interacting with people to much, like to observe more, movement of leaf, color on something, but not in a smart way, i dont conclude anything from observing, no numbers flying around me, that would be epic., also sometimes i feal like i cant move, i get scared im going catatonic so i move my body to prove myself im fine. I've been dosing 5mgs in the morning and at night for around the last two weeks. Feel free to share yours. My anxiety would often take two alternating forms, nervous energy during upswings and severe brain fog during downswings. I tried up to 5 mg but that would give me anxiaty few hours after ingesting, and possible diso feeling tomorow. Zombie like, with thousand yard stare dreaming of suicide. I've always suffered a group of symptoms consistent with ASD-like social anxiety, depression, and ADD. Personally, I don't think its bipolar. By blocking NMDA receptors, mema… This sub is not for venting or for facebook style posts. For those who want to use memantine for treating Alzheimer's disease, a higher dosage is recommended. So i would go back on memantine and lo and behold 2-3 days after i would be a lot less depressed. Should i take memantine again, or some other stuff that effects NMDA, like magnesium l threonate, agmatin sulfate? Conclusions. Larger-scale, randomized controlled trials are necessary before one … Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. Since trying the memantine, my use of caffeine has almost tapered itself. It also takes around 24-48 hours from uuu i think im starting to feel better to yup, im definitely a lot better. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. There is some clinical evidence that it can help people recover from stimulant and opioid addictions. A bit of background, I'm a 24 year old male premed student. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. Have you tried tapering off the caffeine? I'm sorry to hear that, my respond to it has been nothing short of incredible. What I didn't expect was that I would no longer need the Adderall. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. This is my experience with Memantine. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. I am either going to add memantine to this combo or take it alone. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. There's preliminary research supporting its use in bipolar disorder, particularly for mood stabilization and cognitive functioning. Its as if all the background noise in my head just suddenly had been silenced. I wouldnt say im complitely depresion free, i just dont have big clinical depresion any more, which is dream come true. Results From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Brand names. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. Depression; Memantine Dosage. I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. On the other hand, sounds like ADD as well, as you mentioned. Fast forward a month, I've had to stop the Lexapro due to rectal bleeding though I still have a bottle on hand if I hit another major depressive episode. In a previous pre-clinical … Bromantane was slight stimulant. I started spending longer and longer hours at school attempting to study, but couldn't focus for the life of me. I am taking Seroquel 25 mg with 100 mg modafinil and I am completely exhausted and unproductive. I'm also diagnosed with ADHD (in addition to other and suspected psychiatric conditions), and Adderall didn't induce a mood episode for me--though, I was taking (and still take) a mood stabilizer when I started. Did memantine realy helped if im CD free withouth being on memantine anymore? Cookies help us deliver our Services. When adding galantamine, the slope is increased to 0.13, 0.30, and 0.16 for 8, 16, and 24 mg, respectively. So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. Magnetic resonance … To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). Store memantine at room temperature away from moisture and heat. That does potentially sound more along the lines of something like bipolar disorder if you were also feeling really energetic/happy in those bursts, rather than just straight depression. ill do some research and see if i an find anything clinical and empirical to support the anecdotal claims i have but I can tell you that from a personal perspective it does appear to play a role in the cessation of my depression and the modulation of my functional capacity. My state of mind was a bit hard to describe, but the best I can come up with is I was suffering from "mind tetanus." Those that do have at least light/mild effect are: Nac for working memory. But once again, that lasted a good 2 or so weeks and then I was back to being okay like I was before the downswing hit. Addition of DM/Q resulted in clinical improvement in depressive symptomatology. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. Psychostimulants don't necessarily provoke hypo/mania in bipolar patients. Diagnosed BD1 years ago after a similar experience and follow-ups with my psychiatrist.) I felt constantly down, anxious, and helpless. However, the molecular mechanisms underlying the antidepressive properties of memantine in animal and clinical studies still have not been fully explored. ADHD is also commonly comorbid with BD; moreover, the neurocognitive deficits among bipolar patients are well-documented in the literature, and they notably resemble those of ADHD patients. The severity of the condition will also influence how much Memantine to take. Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment. 3. Hi, i was taking around 2 mg of memantine every third or other day. I would constantly start to zone out and studying was accomplished in 5-10 bursts followed by long periods of shit. Yeah it was definitely as rapid of a reaction as one could possibly hope for. Nitrous oxide (N2O, laughing gas) has shown early promise as a rapidly acting treatment for treatment-resistant major depression (1–3). I had shoulder surgery over break and was taking 20mg-30mg oxycodon ED for around 3 weeks. That said, there are side effects to rapid remission of CD. Approximately 25% of the patients stopped the medicine due to adverse reactions. In a separate open-label trial, depressed patients treated with chronic memantine did show some clinical improvement in ratings of their depression symptoms 1 wk after starting daily dosing and continuing for at least 12 wk; however, this study did not contain a placebo control group . Evidence supporting the use of DM/Q in mood disorders is scant at this time, and long-term safety studies in this population are currently lacking. The original plan was to take a 5 week break and try a 110mg trip on a Saturday, but due to this coronavirus pandemic, plans changed drastically. I dont mind those sideefects too much, they are liveable, CD not so much. Press J to jump to the feed. I have strainght to go outside. However, the memantine group averaged significantly greater improvement in scores on both the Montgomery-Åsberg Depression Rating Scale and the Apathy Evaluation Scale, according to the poster abstract. To test if im really less depressed or is this all just placebo i stopped taking memantine (did this test twice). Use memantine regularly to get the most benefit. On a related note, there has been some studies for Memantine in the treatment as a mood stabiliser in Bipolar patients. Granted I've heard people say this wears off starting around week two, but I think if that were the case I would already start seeing the effects slowly lessen whereas I feel as if they are only getting stronger. It's primarily used to protect against future episodes of depression, and it's quite tolerable. I'd be curious to know what sort of neurologic differences are consistent with someone like me who does respond to it very well. It takes 3-4 days since stopping memantine for me to start fealing off, or bad,and since that point around 48 hours for depression to reach full beast mode. Anxiety and stress are my two worst demons and memantine is much better supported as an anxiolytic than it is as a mood stabilizer. Discussion and anecdotes are welcome! So around November after flunking my second anatomy exam (after scoring a 96 on the first one) I drove back home to see my doctor. Ill ask about lamotrigine, but I'm reluctant to switch off of memantine given how effective its been for me thus far. My question is: How long do I need to wait until I can start dosing therapeutically? What should I do? It just increased my anxiety every time. Memantine "Quarantrip" Experience As a forward, the first time I tried memantine was a bit over 5 weeks ago at my private college apartment.The dosage was 73mg and the experience was enjoyable and unique. I've been studying perfectly fine without any stimulants expect ~200mg of caffeine upon waking up. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. What sort of neurologic differences are consistent with MDD, but rather almost like episodic bouts of hysteria they. A day at a starting dose of 0.3-0.5 mg/kg not find the it to be a lot less.! 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